I have a weird soft spot for the harmonica, we had an ancient one when I was a kid that had weight and character, and I wish I still had now. I couldn't ever play a single fucking tune - it's way more comlicated than it looks - but I could make a good, mournful noise.
The best use of the harmonica is obviously in the maestro Ennio's score for Once Upon A Time In The West, but I personally believe the greatest use of the instrument in the past 20 years is the solo that really kicks in about two minute into the Go! Team's Bottle rocket.
Breaks my fuckin' heart every time, I swear..